|Category||powerful anti-estrogen. SERM|
|Positive effects||avoids gynecomastia, decreased water retention and fat. PCT|
|Adverse effects||can reduce the weight gain|
|Dosage||20 days are enough to 40mg by|
This anti estrogen is taken orally and combines wonderfully well Proviron during a medication support during your steroid treatment because of the complementarity of these two products.
Unlike Proviron which is an aromatic anti, the Nolvadex acts as an antagonist of estrogen in preventing them from binding to estrogen receptors (SERM).
End of the 1950 years, pharmaceutical companies are actively looking for a new class of compounds antiestrogens in the hope of developing a contraceptive pill next day.
Arthur L Walpole was an endocrinologist leading a research team from theRIGHT HERE Pharmaceuticals.
This, in 1966, Dora Richardson, a member of the research team synthesized for the first time tamoxifen, Then known as ICI-46, 474.
Walpole and his colleagues filed a British patent covering this compound in 1962, but patent protection on this compound has been rejected several times in the United States.
Tamoxifen has finally received marketing authorization as a fertility treatment, but it does not prove useful for human contraception.
Nolvadex: Clinical Studies
The first clinical studies took place in theChristie Hospital in Manchester in 1971, and showed convincing results in the treatment of advanced breast cancer.
The continuation of tamoxifen development will be enhanced by a second clinical study conducted by Professor Harold WC Ward at Queen Elizabeth Hospital in Birmingham.
The Ward study will bring positive results for drug use with higher doses.
In 1973, following this second study and the importance of the results that emerged, Walpole managed to convince the company ICI Pharmaceuticals regarding the potential importance of the tamoxifen on the market for treatment of breast cancer at an advanced stage.
Will finally follow the long-awaited approval of the patent in the US in 1977.
But the tamoxifen was competing against other hormonal agents in a relatively small market and was not, at this stage, clinically or financially remarkable reports to competition.
It is 1980, and the publication of the first study showing that tamoxifen given in addition to chemotherapy, it greatly improves survival of patients with early breast cancer.
The beneficial effects of tamoxifen on estrogen receptors are however not yet known.
It was after his "mild" side effects profile in number of clinical trials will be prosecuted.
It will take a very serious and 1998 report from the University of Oxford definitively demonstrating that tamoxifen has saved lives, whether in care of breast cancer early or advanced stage.
To date, the tamoxifen is used for the treatment of many disorders.
Besides its use as part of a steroid treatment, We'll see much in detail later, the tamoxifen sees used to counteract precocious puberty (syndrome known as the McCune-Albright syndrome).
Nolvadex and anabolic steroids
When used in support of cure during a cycle of steroidThe Tamoxifen could not be more efficient. It prevents theflavoring the steroid and prevent you from more restrictive side effects, gynecomastia.
During a steroid cycle, Nolvadex is used by bodybuilders that are sensitive to accumulation of estrogen.
The buildup of estrogen can cause many problems, the first of which is the appearance of gynecomastia (growth of breast tissue in men) and the subcutaneous fat and water retention.
You are aware that a major problem when steroid use is the flavoring of these.
These problems will confront you with what is called a feminization phenomenon.
Head of symptoms, gynecomastia.
This disorder causes the appearance of a female breast in male users.
And although this problem can lead to some mockery of your classmates, it is to be taken seriously.
The symptoms are easily identifiable:
Development and breast tenderness, swelling under the nipple, painful breasts and, for the most severe cases, skin ulceration of the breast or nipple discharge blood.
Consult your doctor for more serious symptoms can be an indicator of probable breast cancer.
For the most severe cases, reconstructive surgery may be necessary.
It is therefore important to be vigilant, especially when we know that this can be avoided in a simple and non-binding following a support medication.
Gynecomastia results from an imbalance of your hormones, an estrogen surplus caused by your steroid flavoring.
The degree of this aromatization depend on several factors.
- products used
Firstly some anabolic steroids are undergoing minor flavoring while others have a predisposition aromatization.
Moreover, it is clear that a breach of assays all expose you more to this phenomenon.
Moreover, it is to initiate steroid treatment without thinking support the cure.
This compared returns to play tightrope without a safety net.
And this is where the Nolvadex comes in.
It effectively works by blocking the estrogen receptors thereby preventing the connection between the latter two.
It is important to clarify the difference between the Nolvadex and Clomid.
For these two products, when used together it's their complementarities.
Nolvadex does not prevent the flavor of the steroid in contrast to Proviron but will take the place of estrogen receptor levels doing so as a shield more powerful.
It will also add the ability of this product to increase the natural production of testosterone.
Its direct influence on the hypothalamus by promoting the release ofHGH (Human growth hormone) by the pituitary gland which stimulates the production of Testosterone in the testes.
This advantage is more interesting when you know that taking anabolic steroids reduced the natural production of testosterone.
I would tend to move in the positive effects that the Nolvadex do not have or have very little negative side effects but we will see in the next chapter.
negative effects of Nolvadex
The negative effects associated with use of Nolvadex as part of a support cure during a steroid cycle is minimal.
Compliance with the recommended dose of 20 mg / day usually result in some annoying effects.
In very rare cases nausea or hot flushes were observed but this is still a very small percentage.
Tons of tricks to fight against nausea if you face it, exist.
Take a sweet drink, such as a flat soda kept at room temperature. This remedy is said to calm nausea.
Or even ginger which is one of the anti nausea remedies the oldest and possibly the most effective of all. Prepare in infusion: first peel a piece of rhizome, then chop or grate the equivalent of a heaping teaspoon. Infuse 10 1 in minutes cup boiling water, covering. You can take the warm infusion or slightly cooled. In the absence of fresh ginger, swallow some ginger cookies or chew a piece of candied ginger.
Peppermint ginger closely in terms of its effectiveness in calming the stomach lining. You can use pouches or trade the bulk plant to prepare an infusion. Take in a hot cup whenever you have nausea.
Make a syrup with half a cup of refined sugar and a quarter cup of water. Reheat in a saucepan over medium heat and stir until sugar is completely dissolved. Let cool to room temperature and take one or two teaspoons necessary.
Small precision any time for women users, disruption of the menstrual cycle may occur.
Women using contraception should also be careful.
A side effect (wanted or not) may appear 9 months.
Indeed, the Nolvadex being an anti estrogen, it is logical that if you use the contraceptive pill, the estrogen in the pill will be opposed by the Nolvadex, Which could, in case of unprotected sex lead to pregnancy.
The recommended dosage is 20 mg per day but some users with predisposition has gynecomastia or users who make very big steroid treatment may review 30 mg dosage see 40 mg daily.
When using the Nolvadex in the medical field so that is a different usage and dosage in treatment to support a cycle of steroids, side effects have been observed as a decreased libido.
Le Nolvadex in the medical field is mainly used to fight against breast cancer with significant assays, it is normal that these side effects are mainly women.